Genome Based Cell Population Heterogeneity Promotes Tumorigenicity: The Evolutionary Mechanism of Cancer

Cancer progression represents an evolutionary process where overall genome level changes reflect system instability and serve as a driving force for evolving new systems. To illustrate this principle it must be demonstrated that karyotypic heterogeneity (population diversity) directly contributes to...

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Main Authors: Ye, Christine J., Stevens, Joshua B., Liu, Guo, Bremer, Steven W., Jaiswal, Aruna S., Ye, Karen J., Lin, Ming-Fong, Lawrenson, Lesley, Lancaster, Wayne D., Kurkinen, Markku, Liao, Joshua D., Gairola, C. Gary, Shekhar, Malathy P.V., Narayan, Satya, Miller, Fred R., Heng, Henry H.Q.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778062/
https://ncbi.nlm.nih.gov/pubmed/19115235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21663
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