On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies

For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, it maintains the same robustness against population admixture as traditiona...

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Bibliographic Details
Main Authors: Won, Sungho, Wilk, Jemma B., Mathias, Rasika A., O'Donnell, Christopher J., Silverman, Edwin K., Barnes, Kathleen, O'Connor, George T., Weiss, Scott T., Lange, Christoph
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777973/
https://ncbi.nlm.nih.gov/pubmed/19956679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000741
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