LEPTIN REPLACEMENT RESTORES SUPRASPINAL CHOLINERGIC ANTINOCEPTION IN LEPTIN DEFICIENT OBESE MICE

A single gene deletion causes lack of leptin and obesity in B6.V-Lep(ob) (obese) mice compared to wild-type C57BL/6J (B6) mice. This study compared the phenotype of nociception and supraspinal antinociception in obese and B6 mice by testing two hypotheses: 1) microinjection of cholinomimetics or an...

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Bibliographic Details
Main Authors: Wang, Wenfei, Baghdoyan, Helen A., Lydic, Ralph
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777714/
https://ncbi.nlm.nih.gov/pubmed/19380255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2009.02.003
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