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A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation

The role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S. aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeira-Rey et al. (Science...

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Detalhes bibliográficos
Main Authors: Villaruz, Amer E., Wardenburg, Juliane Bubeck, Khan, Burhan A., Whitney, Adeline R., Sturdevant, Daniel E., Gardner, Donald J., DeLeo, Frank R., Otto, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777534/
https://ncbi.nlm.nih.gov/pubmed/19604047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/604728
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