Peroxisome proliferator-activated receptor-γ ligands induce heme oxygenase-1 in lung fibroblasts by a PPARγ-independent, glutathione-dependent mechanism

Oxidative stress plays an important role in the pathogenesis of pulmonary fibrosis. Heme oxygenase-1 (HO-1) is a key antioxidant enzyme, and overexpression of HO-1 significantly decreases lung inflammation and fibrosis in animal models. Peroxisome proliferator-activated receptor-γ (PPARγ) is a trans...

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Autors principals: Ferguson, Heather E., Thatcher, Thomas H., Olsen, Keith C., Garcia-Bates, Tatiana M., Baglole, Carolyn J., Kottmann, R. M., Strong, Emily R., Phipps, Richard P., Sime, Patricia J.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777492/
https://ncbi.nlm.nih.gov/pubmed/19734319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00148.2009
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