Caveolin-1 mediates endotoxin inhibition of endothelin-1-induced endothelial nitric oxide synthase activity in liver sinusoidal endothelial cells

Endothelin-1 (ET-1) plays a key role in the regulation of endothelial nitric oxide synthase (eNOS) activation in liver sinusoidal endothelial cells (LSECs). In the presence of endotoxin, an increase in caveolin-1 (Cav-1) expression impairs ET-1/eNOS signaling; however, the molecular mechanism is unk...

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Detalhes bibliográficos
Main Authors: Kwok, Willson, Lee, Sang Ho, Culberson, Cathy, Korneszczuk, Katarzyna, Clemens, Mark G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777454/
https://ncbi.nlm.nih.gov/pubmed/20501440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00106.2009
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