Retrograde Viral Vector-Mediated Inhibition of Pontospinal Noradrenergic Neurons Causes Hyperalgesia in Rats

Pontospinal noradrenergic neurons form a component of an endogenous analgesic system and represent a potential therapeutic target. We tested the principle that genetic manipulation of their excitability can alter nociception using an adenoviral vector (AVV-PRS-hKir(2.1)) containing a catecholaminerg...

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Detalhes bibliográficos
Main Authors: Howorth, Patrick W., Thornton, Simon R., O'Brien, Victoria, Smith, Wynne D., Nikiforova, Natalia, Teschemacher, Anja G., Pickering, Anthony E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777275/
https://ncbi.nlm.nih.gov/pubmed/19828800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1699-09.2009
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