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Streamlined Architecture and Glycosylphosphatidylinositol-dependent Trafficking in the Early Secretory Pathway of African Trypanosomes

The variant surface glycoprotein (VSG) of bloodstream form Trypanosoma brucei (Tb) is a critical virulence factor. The VSG glycosylphosphatidylinositol (GPI)-anchor strongly influences passage through the early secretory pathway. Using a dominant-negative mutation of TbSar1, we show that endoplasmic...

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Detalhes bibliográficos
Main Authors: Sevova, Elitza S., Bangs, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777104/
https://ncbi.nlm.nih.gov/pubmed/19759175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-07-0542
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