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The Pseudomonas toxin pyocyanin inhibits the Dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells

The dual oxidase-thiocyanate-lactoperoxidase (Duox/SCN(−)/LPO) system generates the microbicidal oxidant hypothiocyanite in the airway surface liquid by using LPO, thiocyanate, and Duox-derived hydrogen peroxide released from the apical surface of the airway epithelium. This system is effective agai...

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Bibliografiske detaljer
Main Authors: Rada, Balázs, Lekstrom, Kristen, Damian, Sorin, Dupuy, Corinne, Leto, Thomas L.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776642/
https://ncbi.nlm.nih.gov/pubmed/18802092
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