Pyrosequencing assay to rapidly detect clarithromycin resistance mutations in Canadian Helicobacter pylori isolates

BACKGROUND: Mutations at positions 2142 or 2143 in the two-copy 23S ribosomal RNA gene of Helicobacter pylori are highly predictive of in vitro clarithromycin resistance and failure of clarithromycin-containing treatment regimens. OBJECTIVE: To design an assay to rapidly detect these mutations using...

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Autori principali: Slinger, R, Yan, L, Chan, F, Forward, K, Cooper-Lesins, G, Best, L, Haldane, D, van Zanten, S Veldhuyzen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Pulsus Group Inc 2009
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776549/
https://ncbi.nlm.nih.gov/pubmed/19816623
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