Failed gene conversion leads to extensive end processing and chromosomal rearrangements in fission yeast

Loss of heterozygosity (LOH), a causal event in cancer and human genetic diseases, frequently encompasses multiple genetic loci and whole chromosome arms. However, the mechanisms by which such extensive LOH arises, and how it is suppressed in normal cells is poorly understood. We have developed a ge...

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Main Authors: Tinline-Purvis, Helen, Savory, Andrew P, Cullen, Jason K, Davé, Anoushka, Moss, Jennifer, Bridge, Wendy L, Marguerat, Samuel, Bähler, Jürg, Ragoussis, Jiannis, Mott, Richard, A Walker, Carol, Humphrey, Timothy C
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2776099/
https://ncbi.nlm.nih.gov/pubmed/19798055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.265
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