Gene Therapy with Neurogenin 3 and Betacellulin Reverses Major Metabolic Problems in Insulin-Deficient Diabetic Mice

Insulin deficiency in type 1 diabetes leads to disruptions in glucose, lipid, and ketone metabolism with resultant hyperglycemia, hyperlipidemia, and ketonemia. Exogenous insulin and hepatic insulin gene therapy cannot mimic the robust glucose-stimulated insulin secretion (GSIS) from native pancreat...

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Main Authors: Yechoor, Vijay, Liu, Victoria, Paul, Antoni, Lee, Jeongkyung, Buras, Eric, Ozer, Kerem, Samson, Susan, Chan, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775983/
https://ncbi.nlm.nih.gov/pubmed/19819964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0527
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