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Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C

Flow-stimulated net K secretion (J(K)) in the cortical collecting duct (CCD) is mediated by an iberiotoxin (IBX)-sensitive BK channel, and requires an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). The α-subunit of the reconstituted BK channel is phosphorylated by PKA and PKC. To test...

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Main Authors: Liu, Wen, Wei, Yuan, Sun, Peng, Wang, Wen-Hui, Kleyman, Thomas R., Satlin, Lisa M.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775580/
https://ncbi.nlm.nih.gov/pubmed/19656909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90685.2008
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