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Direct observation of the mechanochemical coupling in myosin-V during processive movement

Myosin-Va transports intracellular cargos along actin filaments in cells1. This processive two-headed motor takes multiple 36-nm steps in which the two heads swing forward alternately towards the barbed end of actin driven by ATP hydrolysis2. The ability of myosin-Va to move processively is a functi...

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Detalhes bibliográficos
Main Authors: Sakamoto, Takeshi, Webb, Martin R., Forgacs, Eva, White, Howard D., Sellers, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775414/
https://ncbi.nlm.nih.gov/pubmed/18668042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07188
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