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Dual role for the methyltransferase G9a in the maintenance of β-globin gene transcription in adult erythroid cells
Using a proteomics screen, we have identified the methyltransferase G9a as an interacting partner of the hematopoietic activator NF-E2. We show that G9a is recruited to the β-globin locus in a NF-E2-dependent manner and spreads over the entire locus. While G9a is often regarded as a corepressor, kno...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775297/ https://ncbi.nlm.nih.gov/pubmed/19822740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906769106 |
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