Immunoneutralization of Agmatine Sensitizes Mice to μ-Opioid Receptor Tolerance

Systemically or centrally administered agmatine (decarboxylated arginine) prevents, moderates, or reverses opioid-induced tolerance and self-administration, inflammatory and neuropathic pain, and sequelae associated with ischemia and spinal cord injury in rodents. These behavioral models invoke the...

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Autors principals: Wade, Carrie L., Eskridge, Lori L., Nguyen, H. Oanh X., Kitto, Kelley F., Stone, Laura S., Wilcox, George, Fairbanks, Carolyn A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2009
Matèries:
Neuropharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775255/
https://ncbi.nlm.nih.gov/pubmed/19684255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.155424
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