Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation

Viral infection or reactivation remains a major cause of morbidity and mortality after allogeneic stem cell transplantation. We now show that infusions of single cytotoxic T lymphocyte (CTL) lines (5 × 10(6)-1.35 × 10(8) cells/m(2)) with specificity for 2 commonly detected viruses, Epstein-Barr viru...

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Autores principales: Leen, Ann M., Christin, Anne, Myers, Gary D., Liu, Hao, Cruz, Conrad R., Hanley, Patrick J., Kennedy-Nasser, Alana A., Leung, Kathryn S., Gee, Adrian P., Krance, Robert A., Brenner, Malcolm K., Heslop, Helen E., Rooney, Cliona M., Bollard, Catherine M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Transplantation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774556/
https://ncbi.nlm.nih.gov/pubmed/19700662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-232454
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