Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

Recent reports describe hematopoietic abnormalities in mice with targeted instability of the mitochondrial genome. However, these abnormalities have not been fully described. We demonstrate that mutant animals develop an age-dependent, macrocytic anemia with abnormal erythroid maturation and megalob...

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Hauptverfasser: Chen, Michael L., Logan, T. Daniel, Hochberg, Maryann L., Shelat, Suresh G., Yu, Xiang, Wilding, Gregory E., Tan, Wei, Kujoth, Gregory C., Prolla, Tomas A., Selak, Mary A., Kundu, Mondira, Carroll, Martin, Thompson, James E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2009
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774546/
https://ncbi.nlm.nih.gov/pubmed/19734452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-169474
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