Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have complex actions in angiogenesis and vascular remodeling due to their effects on Tie2 receptor signaling. Ang2 blocks Ang1-mediated activation of Tie2 in endothelial cells under certain conditions but is a Tie2 receptor agonist in others. We examin...

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Bibliografiske detaljer
Main Authors: Falcón, Beverly L., Hashizume, Hiroya, Koumoutsakos, Petros, Chou, Jeyling, Bready, James V., Coxon, Angela, Oliner, Jonathan D., McDonald, Donald M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2009
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774078/
https://ncbi.nlm.nih.gov/pubmed/19815705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090391
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