Double-Stranded DNA Activates Glomerular Endothelial Cells and Enhances Albumin Permeability via a Toll-Like Receptor-Independent Cytosolic DNA Recognition Pathway

Viral DNA induces potent antiviral immunity by activating dendritic cells; however, the mechanism governing viral DNA-mediated triggering or aggravation of glomerulonephritis is unknown. Glomerular endothelial cells (GEnCs) do not express toll-like receptor (TLR)9, the only DNA-specific TLR. We ther...

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Detalhes bibliográficos
Principais autores: Hägele, Holger, Allam, Ramanjaneyulu, Pawar, Rahul D., Reichel, Christoph A., Krombach, Fritz, Anders, Hans-Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774054/
https://ncbi.nlm.nih.gov/pubmed/19834059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090182
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