Periconceptional Maternal Folic Acid Use of 400 µg per Day Is Related to Increased Methylation of the IGF2 Gene in the Very Young Child

BACKGROUND: Countries worldwide recommend women planning pregnancy to use daily 400 µg of synthetic folic acid in the periconceptional period to prevent birth defects in children. The underlying mechanisms of this preventive effect are not clear, however, epigenetic modulation of growth processes by...

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Main Authors: Steegers-Theunissen, Régine P., Obermann-Borst, Sylvia A., Kremer, Dennis, Lindemans, Jan, Siebel, Cissy, Steegers, Eric A., Slagboom, P. Eline, Heijmans, Bastiaan T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773848/
https://ncbi.nlm.nih.gov/pubmed/19924280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007845
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