Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects

Using surface plasmon resonance (SPR) and electrospray mass spectrometry (ESI-MS), proinsulin C-peptide was found to influence insulin-insulin interactions. In SPR with chip-bound insulin, C-peptide mixed with analyte insulin increased the binding, while alone C-peptide did not. A control peptide wi...

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Main Authors: Shafqat, J., Melles, E., Sigmundsson, K., Johansson, B. -L., Ekberg, K., Alvelius, G., Henriksson, M., Johansson, J., Wahren, J., Jörnvall, H.
Format: Artigo
Sprog:Inglês
Udgivet: Birkhäuser-Verlag 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773842/
https://ncbi.nlm.nih.gov/pubmed/16845606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-006-6204-6
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