Phase I Study of the Safety, Tolerability, and Pharmacokinetics of Oral CP-868,596, a Highly Specific Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor in Patients With Advanced Cancers

PURPOSE: This phase I, first-in-human study evaluated the safety, tolerability, pharmacokinetics, and maximum-tolerated dose (MTD) of an oral platelet-derived growth factor receptor inhibitor, CP-868,596. PATIENTS AND METHODS: Patients with advanced solid tumors were eligible. Dose escalations were...

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Detalhes bibliográficos
Main Authors: Lewis, Nancy L., Lewis, Lionel D., Eder, Joseph P., Reddy, Nandi J., Guo, Feng, Pierce, Kristen J., Olszanski, Anthony J., Cohen, Roger B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2009
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773478/
https://ncbi.nlm.nih.gov/pubmed/19738123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.21.8487
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