The Mechanism of the Reaction Catalyzed by Uronate Isomerase Illustrates How an Isomerase May Have Evolved from a Hydrolase within the Amidohydrolase Superfamily

Uronate isomerase (URI) catalyzes the reversible isomerization of D-glucuronate to D-fructuronate and of D-galacturonate to D-tagaturonate. URI is a member of the amidohydrolase superfamily (AHS), a highly divergent group of enzymes that catalyzes primarily hydrolytic reactions. The chemical mechani...

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Bibliografiske detaljer
Main Authors: Nguyen, Tinh T., Fedorov, Alexander A., Williams, LaKenya, Fedorov, Elena V., Li, Yingchun, Xu, Chengfu, Almo, Steven C., Raushel, Frank M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773443/
https://ncbi.nlm.nih.gov/pubmed/19678710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901046x
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