Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice

BACKGROUND: Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. METHODOLOGY/PRINCIPAL FINDIN...

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Main Authors: Kimura, Hiroaki J., Chen, Cindy Y., Tzou, Shey-Cherng, Rocchi, Roberto, Landek-Salgado, Melissa A., Suzuki, Koichi, Kimura, Miho, Rose, Noel R., Caturegli, Patrizio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773418/
https://ncbi.nlm.nih.gov/pubmed/19924240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007857
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