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Flexibility in the Inducer Binding Region is Crucial for Allostery in the Escherichia coli Lactose Repressor
Lactose repressor protein (LacI) utilizes an allosteric mechanism to regulate transcription in E. coli, and the transition between inducer- and operator-bound states has been simulated by targeted molecular dynamics (TMD). The side chains of amino acids 149 and 193 interact and were predicted by TMD...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2772868/ https://ncbi.nlm.nih.gov/pubmed/19368358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9002343 |
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