Homodimerization of the Meq Viral Oncoprotein Is Necessary for Induction of T-Cell Lymphoma by Marek's Disease Virus

Marek's disease virus (MDV) is a lymphotropic alphaherpesvirus that induces fatal rapid-onset T-cell lymphomas in chickens, its natural host. The MDV-encoded nuclear oncoprotein Meq is essential for lymphomagenesis and acts as a regulator of transcription. Meq has structural features, including...

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Detalhes bibliográficos
Main Authors: Brown, Andrew C., Smith, Lorraine P., Kgosana, Lydia, Baigent, Susan J., Nair, Venugopal, Allday, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772798/
https://ncbi.nlm.nih.gov/pubmed/19692466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01393-09
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