Disruption of Smad4 in Odontoblasts Causes Multiple Keratocystic Odontogenic Tumors and Tooth Malformation in Mice

Keratocystic odontogenic tumors (KCOTs) are cystic epithelial neoplasias with a high recurrence rate. However, the molecular mechanisms underlying the initiation and progression of KCOTs are still largely unknown. Here, we show that specific ablation of Smad4 in odontoblasts unexpectedly resulted in...

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Detalhes bibliográficos
Main Authors: Gao, Yuanrong, Yang, Guan, Weng, Tujun, Du, Juan, Wang, Xuejiu, Zhou, Jian, Wang, Songlin, Yang, Xiao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772727/
https://ncbi.nlm.nih.gov/pubmed/19703995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00706-09
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