The Heptad Repeat 2 Domain Is a Major Determinant for Enhanced Human Immunodeficiency Virus Type 1 (HIV-1) Fusion and Pathogenicity of a Highly Pathogenic HIV-1 Env

Human immunodeficiency virus type 1 (HIV-1)-mediated depletion of CD4(+) lymphocytes in an infected individual is the hallmark of progression to AIDS. However, the mechanism for this depletion remains unclear. To identify mechanisms of HIV-1-mediated CD4 T-cell death, two similar viral isolates obta...

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Bibliografiska uppgifter
Huvudupphovsmän: Sivaraman, Vijay, Zhang, Liguo, Meissner, Eric G., Jeffrey, Jerry L., Su, Lishan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2009
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772666/
https://ncbi.nlm.nih.gov/pubmed/19726524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00649-09
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