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Cyclic GMP Kinase and RhoA Ser188 Phosphorylation Integrate Pro- and Antifibrotic Signals in Blood Vessels

Vascular fibrosis is a major complication of hypertension and atherosclerosis, yet it is largely untreatable. Natriuretic peptides (NPs) repress fibrogenic activation of vascular smooth muscle cells (VSMCs), but the intracellular mechanism mediating this effect remains undetermined. Here we show tha...

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Detalhes bibliográficos
Main Authors: Sawada, Naoki, Itoh, Hiroshi, Miyashita, Kazutoshi, Tsujimoto, Hirokazu, Sone, Masakatsu, Yamahara, Kenichi, Arany, Zoltan P., Hofmann, Franz, Nakao, Kazuwa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772562/
https://ncbi.nlm.nih.gov/pubmed/19737918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00225-09
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