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Francisella tularensis Induces Extensive Caspase-3 Activation and Apoptotic Cell Death in the Tissues of Infected Mice

Although Francisella tularensis subsp. tularensis is known to cause extensive tissue necrosis, the pathogenesis of tissue injury has not been elucidated. To characterize cell death in tularemia, C57BL/6 mice were challenged by the intranasal route with type A F. tularensis, and the pathological chan...

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Detalhes bibliográficos
Main Authors: Wickstrum, Jason R., Bokhari, Sirosh M., Fischer, Jeffrey L., Pinson, David M., Yeh, Hung-Wen, Horvat, Rebecca T., Parmely, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772556/
https://ncbi.nlm.nih.gov/pubmed/19703976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00246-09
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