Modulation of the Heme Electronic Structure and Cystathionine β-synthase Activity by Second Coordination Sphere Ligands: The Role of Heme Ligand Switching in Redox Regulation

In humans, cystathionine β-synthase (CBS) is a hemeprotein, which catalyzes a pyridoxal phosphate (PLP)-dependent condensation reaction. Changes in the heme environment are communicated to the active site, which is ~20 Å away. In this study, we have examined the role of H67 and R266, which are in th...

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Hlavní autoři: Singh, Sangita, Madzelan, Peter, Stasser, Jay, Weeks, Colin L., Becker, Donald, Spiro, Thomas G., Penner-Hahn, James, Banerjee, Ruma
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772092/
https://ncbi.nlm.nih.gov/pubmed/19232736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2009.01.009
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