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Stochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico
The mitochondrial free radical theory of aging (mFRTA) implicates Reactive Oxygen Species (ROS)-induced mutations of mitochondrial DNA (mtDNA) as a major cause of aging. However, fifty years after its inception, several of its premises are intensely debated. Much of this uncertainty is due to the la...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771766/ https://ncbi.nlm.nih.gov/pubmed/19936024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000572 |
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