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Dual and opposing roles of primary cilia in medulloblastoma development

Recent work has shown that primary cilia are essential for Hh signaling during mammalian development1–9. It is also known that aberrant Hedgehog (Hh) signaling can lead to cancer10, but the role of primary cilia in oncogenesis is not known. Cerebellar granule neuron precursors (GNPs) can give rise t...

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Bibliografiske detaljer
Main Authors: Han, Young-Goo, Kim, Hong Joo, Dlugosz, Andrzej A., Ellison, David W., Gilbertson, Richard J., Alvarez-Buylla, Arturo
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771737/
https://ncbi.nlm.nih.gov/pubmed/19701203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2020
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