Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells

Increasing evidence suggests that cancer cells (relative to normal cells) have altered mitochondrial electron transport chains (ETC) that are more likely to form reactive oxygen species (ROS; i.e., O(2)(•-) and H(2)O(2)) resulting in a condition of chronic metabolic oxidative stress, that maybe comp...

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Autores principales: Fath, Melissa A., Diers, Anne R., Aykin-Burns, Nukhet, Simons, Andrean L., Hua, Lei, Spitz, Douglas R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771689/
https://ncbi.nlm.nih.gov/pubmed/19411865
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