THE CONTRIBUTION OF CONFORMATIONAL ADJUSTMENTS AND LONG-RANGE ELECTROSTATIC FORCES TO THE CD2/CD58 INTERACTION

CD2 is a T cell surface molecule that enhances T and Natural Killer cell function by binding its ligands CD58 (humans) and CD48 (rodents) on antigen presenting or target cells. Here we show that the CD2/CD58 interaction is enthalpically-driven and accompanied by unfavourable entropic changes. Taken...

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Autori principali: Kearney, Alice, Avramovic, Adam, Castro, Mónica A. A., Carmo, Alexandre M., Davis, Simon J., van der Merwe, P. Anton
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771598/
https://ncbi.nlm.nih.gov/pubmed/17344209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700829200
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