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Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations

Prostasin or human channel-activating protease 1 has been reported to play a critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel. Here, the structure of the extracellular portion of the membrane associated serine protease has...

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Hlavní autoři: Spraggon, Glen, Hornsby, Michael, Shipway, Aaron, Tully, David C, Bursulaya, Badry, Danahay, Henry, Harris, Jennifer L, Lesley, Scott A
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771310/
https://ncbi.nlm.nih.gov/pubmed/19388054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.118
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