Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis

The critical processes of mitochondrial fission and fusion are regulated by members of the dynamin family of GTPases. Imbalances in mitochondrial fission and fusion contribute to neuronal cell death. For example, increased fission mediated by the dynamin-related GTPase, Drp1, or decreased fusion res...

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Main Authors: Loucks, F. Alexandra, Schroeder, Emily K., Zommer, Amelia E., Hilger, Shea, Kelsey, Natalie A., Bouchard, Ron J., Blackstone, Craig, Brewster, Jay L., Linseman, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771186/
https://ncbi.nlm.nih.gov/pubmed/19046944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.10.081
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