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Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

Epithelial-mesenchymal crosstalk is essential for tissue morphogenesis, but incompletely understood. Postnatal mammary gland development requires epidermal growth factor receptor (EGFR) and its ligand amphiregulin (AREG), which generally must be cleaved from its transmembrane form in order to functi...

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Hlavní autoři: Sternlicht, Mark D., Sunnarborg, Susan W., Kouros-Mehr, Hosein, Yu, Ying, Lee, David C., Werb, Zena
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771180/
https://ncbi.nlm.nih.gov/pubmed/16079154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.01966
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