Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

Epithelial-mesenchymal crosstalk is essential for tissue morphogenesis, but incompletely understood. Postnatal mammary gland development requires epidermal growth factor receptor (EGFR) and its ligand amphiregulin (AREG), which generally must be cleaved from its transmembrane form in order to functi...

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Bibliographic Details
Main Authors: Sternlicht, Mark D., Sunnarborg, Susan W., Kouros-Mehr, Hosein, Yu, Ying, Lee, David C., Werb, Zena
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771180/
https://ncbi.nlm.nih.gov/pubmed/16079154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.01966
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