Whole-body Sleeping Beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality

The Sleeping Beauty (SB) transposon system has been used as a somatic mutagen to identify candidate cancer genes. In previous studies, efficient leukemia/lymphoma formation on an otherwise wild-type genetic background occurred in mice undergoing whole-body mobilization of transposons, but was accomp...

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Autori principali: Collier, Lara S., Adams, David J., Hackett, Christopher S., Bendzick, Laura E., Akagi, Keiko, Davies, Michael N., Diers, Miechaleen D., Rodriguez, Fausto J., Bender, Aaron M., Tieu, Christina, Matise, Ilze, Dupuy, Adam J., Copeland, Neal G., Jenkins, Nancy A., Hodgson, J. Graeme, Weiss, William A., Jenkins, Robert B., Largaespada, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771123/
https://ncbi.nlm.nih.gov/pubmed/19843846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1760
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