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A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit
Escherichia coli DbpA is an ATP-dependent RNA helicase with specificity for hairpin 92 of 23S ribosomal RNA, an important part of the peptidyl transferase center. The R331A active site mutant of DbpA confers a dominant slow growth and cold sensitive phenotype when overexpressed in E. coli containing...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2009
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770675/ https://ncbi.nlm.nih.gov/pubmed/19734347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp711 |
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