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Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr

BACKGROUND: Tpr is a large protein with an extended coiled-coil domain that is localized within the nuclear basket of the nuclear pore complex. Previous studies [1] involving antibody microinjection into mammalian cells suggested a role for Tpr in nuclear export of proteins via the CRM1 export recep...

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Main Authors: Ben-Efraim, Iris, Frosst, Phyllis D, Gerace, Larry
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770460/
https://ncbi.nlm.nih.gov/pubmed/19835572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-10-74
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