Apoptotic and chemotherapeutic properties of iron (III)-salophene in an ovarian cancer animal model

The cytotoxicity of organometallic compounds iron(III)-, cobalt(III)-, manganese(II)-, and copper(II)-salophene (-SP) on platinum-resistant ovarian cancer cell lines was compared. Fe-SP displayed selective cytotoxicity (IC(50) at ~1 μM) against SKOV-3 and OVCAR-3 cell lines while Co-SP caused cytoto...

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Detalhes bibliográficos
Main Authors: Lange, Thilo S, McCourt, Carolyn, Singh, Rakesh K, Kim, Kyu Kwang, Singh, Ajay P, Luisi, Brian S, Alptürk, Onur, Strongin, Robert M, Brard, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2009
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769229/
https://ncbi.nlm.nih.gov/pubmed/19920918
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