Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice

Mice deficient in the hemochromatosis gene, Hfe, have attenuated inflammatory responses to Salmonella infection associated with decreased macrophage TNF-α and IL-6 biosynthesis after exposure to LPS. In this study, we show that the abnormal cytokine production is related to impaired TLR4 signaling....

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Autores principales: Wang, Lijian, Harrington, Lynne, Trebicka, Estela, Shi, Hai Ning, Kagan, Jonathan C., Hong, Charles C., Lin, Herbert Y., Babitt, Jodie L., Cherayil, Bobby J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2009
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769199/
https://ncbi.nlm.nih.gov/pubmed/19809161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39939
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