Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2–dependent fibrinolysis

When plasma levels of homocysteine (HC), a thiol amino acid formed upon methionine demethylation, exceed 12 μM, individuals are at increased risk of developing large vessel atherothrombosis and small vessel dysfunction. The annexin A2 complex (termed “A2”) is the cell surface coreceptor for plasmino...

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Autors principals: Jacovina, Andrew T., Deora, Arunkumar B., Ling, Qi, Broekman, M. Johan, Almeida, Dena, Greenberg, Caroline B., Marcus, Aaron J., Smith, Jonathan D., Hajjar, Katherine A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769184/
https://ncbi.nlm.nih.gov/pubmed/19841537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39591
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