Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction

TNF-α-mediated apoptosis is enhanced in aged rodent muscles, suggesting that this pathway may be involved in sarcopenia. Interleukin-15 (IL-15), a muscle-derived anabolic cytokine, mitigates muscle wasting and apoptosis in cachectic rats. This effect is thought to occur through inhibition of TNF-α-t...

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Main Authors: Marzetti, Emanuele, Carter, Christy S., Wohlgemuth, Stephanie E., Lees, Hazel A., Giovannini, Silvia, Anderson, Barbara, Quinn, LeBris S., Leeuwenburgh, Christiaan
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768529/
https://ncbi.nlm.nih.gov/pubmed/19396981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2008.12.008
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