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Maleimide conjugation markedly enhances the immunogenicity of both human and murine idiotype-KLH vaccines
The collection of epitopes present within the variable regions of the tumor-specific clonal immunoglobulin expressed by B cell lymphomas (idiotype, Id) can serve as a target for active immunotherapy. Traditionally, tumor-derived Id protein is chemically-conjugated to the immunogenic foreign carrier...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768258/ https://ncbi.nlm.nih.gov/pubmed/19046770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.10.020 |
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