Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats

Chronic, excessive ethanol intake can increase retinoic acid (RA) catabolism by inducing cytochrome P450 2E1 (CYP2E1). Vitamin E (VE) is an antioxidant implicated in CYP2E1 inhibition. In the current study, we hypothesized that VE supplementation inhibits CYP2E1 and decreases RA catabolism, thereby...

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Huvudupphovsmän: Chung, Jayong, Veeramachaneni, Sudipta, Liu, Chun, Mernitz, Heather, Russell, Robert M., Wang, Xiang-Dong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768078/
https://ncbi.nlm.nih.gov/pubmed/19854382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nutres.2009.09.008
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