PRECLINICAL EVALUATION OF INNATE IMMUNITY TO BACULOVIRUS GENE THERAPY VECTORS IN WHOLE HUMAN BLOOD

Interactions of gene therapy vectors with human blood components upon intravenous administration have a significant effect on vector efficacy and patient safety. Here we describe methods to evaluate these interactions and their effects in whole human blood, using baculovirus vectors as a model. Opso...

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Detalhes bibliográficos
Main Authors: Georgopoulos, Lindsay J, Elgue, Graciela, Sanchez, Javier, Dussupt, Vincent, Magotti, Paola, Lambris, John D, Tötterman, Thomas H, Maitland, Norman J, Nilsson, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767513/
https://ncbi.nlm.nih.gov/pubmed/19665799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.07.008
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