Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cells

BACKGROUND: The combination therapy of interferon (IFN)-alpha and 5-fluorouracil (5-FU) improved the prognosis of the patients with hepatocellular carcinoma (HCC). To determine the molecular mechanisms of the anti-tumor and anti-angiogenic effects, we examined the direct anti-proliferative effects o...

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Detalhes bibliográficos
Main Authors: Wada, Hiroshi, Nagano, Hiroaki, Yamamoto, Hirofumi, Noda, Takehiro, Murakami, Masahiro, Kobayashi, Shogo, Marubashi, Shigeru, Eguchi, Hidetoshi, Takeda, Yutaka, Tanemura, Masahiro, Umeshita, Koji, Doki, Yuichiro, Mori, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2767355/
https://ncbi.nlm.nih.gov/pubmed/19821965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-361
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